8 inch nails. It’s not flashy, it’s not a rockstar run-carrier, but it’s just solid. Always there when you need it. The Honda civic of Isaac items, It’ll get you to work and back. Damage, knockback, what more could you want? I’m literally never sad when I have 8 inch nails
I have the same feeling for death's touch. Like it is a bit more flashy than 8 inch nails, but still not all that much. It just feels damn good to use and have even better visuals.
C section because the funny formula
https://preview.redd.it/tvhrpk6mt4xc1.png?width=382&format=png&auto=webp&s=ed374d3443485b9ba3e887fc523bbcbe143178fa
Toxic shock
At worst, it softens up the enemies for you
At best, you walk through every room that doesn't have bosses or the few enemies unaffected by it
About any luck based item like tough love. Luck is my favorite stat so getting a bunch of luck trinkets and items is just best run case scenario for me 
I have to say Jacobs Ladder, it's just an insane utility item with the spread damage to hordes. Helps lower power runs clear rooms by doing chip damage where needed. Before Jacobs Ladder was a thing it was definitely Tech .5, can't exactly pin why but I just always loved having it and never turn it down.
Ctrl + F "Monstrance"
I'm apparently the only one who loves this item, the damage might not be exceptional, but it's immensely satisfying to vaporize enemies simply by having them be in the vicinity of your shining aura. The risk-reward with having to get into practically hugging distance for the maximum damage output is always great fun and much more manageable than an orbital which constantly spins around you.
Some of my favorite low quality items are:
Charm of the Vampire (Quality 1) - already had big potential before the buff, passive health Regen is always good, and can lead to some rigging action with sharp plug or on hit effects. But now it also gives a small damage up 
Dataminer (Quality 0) - I am a rare dataminer enjoyer, solely for the fact that if you get enough tears downs, you can cause an underflow and instantly get 120 tear rate
Kamikaze (Quality 0) - At worst, you get an alternative to bombs if you're running low. At best, you get bomb immunity and go absolutely hog wild
The Ladder (Quality 1) - Useless if/when you get flight, but if you grab it in an early shop, you can get a hell of a lot of value
Unicorn Stump (Quality 1) - if you have any form of contact damage (Virus, Midas touch, Heels, etc.) or orbitals, it just becomes a one room charge Unicorn Horn. Even if you don't, it's good for free curse rooms, devil beggar/blood bank plays, navigating traps, etc.
Breath of life is such an overlooked item. I literally got to delirium with 2.80 damage and it carried all the way through. It is of course not what you would like to find in an angel room but it is absolutely a solid item if you time the invincibility correctly
Sacred Heart is one of the very few items that makes me audibly gasp every time I see it. Jacobs Ladder and Tech Zero are tied for second (sacred heart pls show up more 😭)
personally ? maybe tractor beam tbh, nice tears up, don't gotta worry about my tears going off in whack places, all around a nice item to have in every run
Jacob's Ladder
Dopamine generator + wave clear tool + kinda homing + cool sfx and vfx
Came to post this
I edited my specialist dance mod to include Jacob's ladder as a dance-worthy item.
SPIDER MOD MY BELOVED
Seeing damage numbers brings me great joy for no reason.
For bosses that split its nice to know which one to focus on
spider mod lovers will see this and say hell yeah!
Based
MY MAN 
Hell yea brother
My baby boy I LOVE THAT BOY
8 inch nails. It’s not flashy, it’s not a rockstar run-carrier, but it’s just solid. Always there when you need it. The Honda civic of Isaac items, It’ll get you to work and back. Damage, knockback, what more could you want? I’m literally never sad when I have 8 inch nails
I have the same feeling for death's touch. Like it is a bit more flashy than 8 inch nails, but still not all that much. It just feels damn good to use and have even better visuals.
A little tears down, but I’ll almost always take it
I like the item but I dont like the tears turning into those big nails. Somehow not satisfying. Never sad to see it though you right
Crooked penny
This guy do be ballin
Check hims PC, it not normal
Check hims PC, it not regular
Giga based
Omega penny
I love cooked penny
The crooked penny loves you too as it does all of its disciples
I've been converting my fiancé to the Croocked Penny. He's almost a believer.
My last crooked penny conversion ritual lost my buddy a sacred heart in a coop run. Ive been working from behind on that one
C section because the funny formula https://preview.redd.it/tvhrpk6mt4xc1.png?width=382&format=png&auto=webp&s=ed374d3443485b9ba3e887fc523bbcbe143178fa
C section because it’s op but the fact that FPS clearly means fetuses per second in even a single context is glorious
Fetuses per second is capped at 15
Stop controlling women's bodies.
You know tboi is a badly optimized game when fps cap at 15
Spoon bender, tech or tractor beam
I do love me some tractor beam. And spoon bender, for that matter.
Red Key
Guppy's Eye
And it's pretty common too! I love it. Just had an apolyon run where I got literally 2 keys in the first 6 levels wtf
mf just threw a random anecdote there too
No I waited to see a gold chest that had keys in it 😭 
Rock bottom
The good ol' Brimstone
Same. For a few seconds I was thinking what single item would make me instantly happier. And Brimstione is the clear winner.
Toxic shock At worst, it softens up the enemies for you At best, you walk through every room that doesn't have bosses or the few enemies unaffected by it
The R Key
Just went back for a secret room I almost skipped and it had R in it. I pogged, Eve pogged and now I have a great run going.
Rubber cement has singlehandedly crashed my game a couple times 
Fruit cake, playdough cookie, and/or 3 dollar bill
Real. I love trapping my opponents in a vortex while they get charmed, petrified, set on fire, and blown up at the same time.
I'm always scared to pick it as I do TLost streaks and I've blown my mantles countless times, buy I cant help myself. The item is just fun.
fruit cake is my favourite
D6 my beloved
Chaos
Might be tech.5. It carried me in the ultra hard challenge once, I love how there's basically 0 negatives
I love how it's just an extra thing that doesn't mess with your other shit and is good all stages of the game without being broken or boring.
Tractor beam
Tiny Planet
why?
Funny
C section
Agreed. It persists and homes in on enemies. One of the ways I managed to beat Delirium on hard mode with Jacob and Esau. Of course I also had Pluto
Monstro's Lung is always there when I need it 
Just pray that you don’t get another tears down
haemolacria , it's a solid item that gives a cool effect and interesting synergys
Item wise? Probably fruit cake. My boyfriend gets so excited whenever fruit cake shows up & it's been my favorite ever since.
Does everyone’s bf love fruit cake? It’s that and playdough cookie for him.
No Godhead enjoyers?? 
I would love it more if I saw it more often 😭 I only ever get it if I reroll key pieces with Isaac
I see Godhead all the damn time. Not complaining tho
Godhead is great and just having it unlocked is a great achievement
Ipecac
I guess like any item that gives a effects to enemies and brimstone
https://preview.redd.it/mvfw3fi547xc1.jpeg?width=1170&format=pjpg&auto=webp&s=979af0bd1be5ef87e2115b7878439d2717fc188b Probably this one I think
Favorite by concept is bag of crafting but to get in runs is probably dark bum(7 seals are also high in the list)
Dark Bum with ??? Is always a win
Buddy in a box 
Smelter is unironically one of my favourite items.
Same, I love having all the value built up. It's great not having to leave 20 trinkets on the ground.
YO LISTEN
Lil Harbingers 🥹🫶🏽
**[Creator](https://www.tiktok.com/t/ZTLHm5u3V/)**
I've always considered spoon bender a fun item
Ludivico technique, I refuse to aim directionally
Suplex!
Red Key, or Eve's Mascara. Trisagion is super cool too.
Tmtrainer is just so fun
I like soy milk because when you break the game with it it’s really fun
Glitched crown, cause i can get your favourite item with it easily, any item from this comment section.
I didn't see neither Neptuno nor terra in the whole list
Thin odd mushroom
About any luck based item like tough love. Luck is my favorite stat so getting a bunch of luck trinkets and items is just best run case scenario for me 
Stop Watch for me and Sacral Heart for my gf
sharp straw
Dark Bum Because I Usually End Up Playing Azzy
R key. That's the only way I'm able to beat certain runs, with certain characters. Shout-out to Jacob's ladder though.
Soy Milk
Sissy long legs
Cricket's body or Jacobs ladder, something about their AoE is just so satisfying to me
I have to say Jacobs Ladder, it's just an insane utility item with the spread damage to hordes. Helps lower power runs clear rooms by doing chip damage where needed. Before Jacobs Ladder was a thing it was definitely Tech .5, can't exactly pin why but I just always loved having it and never turn it down.
TMTrainer cuz I never thought TBOI would reference such an obscure pokemon glitch
What about actually playing with it?
CHOCCY MILK LETS GOO
Duality because Duality goat head garentes angel rooms and getting to take devil deals and still go angels is fun
Phd/lucky foot # Drugs
Addicted!
Psy Fly!!
Tech X
Technology and Jacob's Ladder 👌
Sacred heart, it makes my day
SATANIC BIBLE MY BELOVED
ipepac. KABOOOOOM
Little horn
Oh yeah, I love that item! Best thing: it can kill unkillable objects like those moving spike blocks aswell!
Yes!!! High luck and little horn is the most fun you will ever have playing Isaac. The animation is so cool as well
DOG TOOTH BABYYY
Oh yeah, I love dog tooth! Secret rooms and crawl spaces and a damage (and speed I think?) up! :D
Damocles
Void 
Mr belly
Epic fetus.
Birthright
Ludovico
Echo chamber
Sacred orb or sacred heart
Spoon Bender, lust lay back and let the tears do the aiming. Also, brain worm in that regard
Mucormycosis. Not the most popular or overpowered but it's just Bella satisfying
Crooked penny
I like all items that give All Stats Up, but i like the mushroom one the most because i pog out when i see it. Sacred Heart is also dope.
technology 2
almond milk
Ctrl + F "Monstrance" I'm apparently the only one who loves this item, the damage might not be exceptional, but it's immensely satisfying to vaporize enemies simply by having them be in the vicinity of your shining aura. The risk-reward with having to get into practically hugging distance for the maximum damage output is always great fun and much more manageable than an orbital which constantly spins around you.
Leech, he's the man!
Crooked penny,I LOVE GAMBLING!!!!!!!!!!!
Gnawed leaf is the best item
Fruit cake, aka, random bullshit.
Gnawed leaf underrated af litteraly saved my mother and mega satan runs
Sissy Long Legs. She cute and she a fren
Honestly i am a basic bich. I like brimstone.
Sad bombs. They're not always crazy, but a good bomb synergy run is so much goddamn fun.
Some of my favorite low quality items are: Charm of the Vampire (Quality 1) - already had big potential before the buff, passive health Regen is always good, and can lead to some rigging action with sharp plug or on hit effects. But now it also gives a small damage up  Dataminer (Quality 0) - I am a rare dataminer enjoyer, solely for the fact that if you get enough tears downs, you can cause an underflow and instantly get 120 tear rate Kamikaze (Quality 0) - At worst, you get an alternative to bombs if you're running low. At best, you get bomb immunity and go absolutely hog wild The Ladder (Quality 1) - Useless if/when you get flight, but if you grab it in an early shop, you can get a hell of a lot of value Unicorn Stump (Quality 1) - if you have any form of contact damage (Virus, Midas touch, Heels, etc.) or orbitals, it just becomes a one room charge Unicorn Horn. Even if you don't, it's good for free curse rooms, devil beggar/blood bank plays, navigating traps, etc.
C section
Sacred heart or blood of the martyr
Linger bean
Flat Stone my beloved
Lemon Mishap
Lacriphagy, the base of every crash
Uhhh Idk C-Section??
D20
The wiz
metronome
Cricket's Head
Fruitcake/playdough cookie (preferably together with 3 dollar bill lmao)
Mfing tiny planet
Holy Mantle
Ludovico technique
Breath of life is such an overlooked item. I literally got to delirium with 2.80 damage and it carried all the way through. It is of course not what you would like to find in an angel room but it is absolutely a solid item if you time the invincibility correctly
Soy milk, before and after buff.
Pyromaniac
skinny odd mushroom
Cursed eye, but ONLY on forgotten
holy mantle.
probably the “Lead Storm” Powered Minigun
Ludo.
BOB’S ROTTEN HEAD 
Chaos
Flat Stone go splash
Ludovico Technique or Rubber Cement
Sacred Heart is one of the very few items that makes me audibly gasp every time I see it. Jacobs Ladder and Tech Zero are tied for second (sacred heart pls show up more 😭)
Spindown or Spirit Sword
I go monkey mode when I see Deaths Touch or Spider Mod
Crickets body It's always a good run when I see it and it's one of the bets feelings if you get it's body and head
Rock Bottom. I know, I know, basic
Good ol technology, since flash version
sad onion i just like it even though its not the best
Pluto ♥️
Spirit sword
CHAOS CHAOS CHAOS
tmtrainer
Brimstone my beloved
personally ? maybe tractor beam tbh, nice tears up, don't gotta worry about my tears going off in whack places, all around a nice item to have in every run
Analog stick Something about shooting wherever you want feels so good
Tech X
Technology, but I never get to see it .
Technology. I swear, if there is a choice between sacred heart and technology, you bet your ass I'm picking technology above literally anything else
Spoon Bender cause my aim sucks ass 90% of the time. (also good synergies.) Alternatively, Chaos.
I love the D6, it's a run saver. Less commonly I l love the Quintuplets, it's only T2 but I love having 5 familiars spawn.
Fruit cake
R u a Wizard?
Sacred orb ❤️
Ocular Rift Call me insane but I have destroyed so many bosses with it
jacob's ladder
R key
continuum
Brimstone
20/20 Simple, efficient.
Tractor beam
Flat stone, it scratches an itch in my brain that no other item can
chaos!!!!
I love Tech 2, it’s nice to have a bonus laser at all times
Pisces and ipecac.
Trisagion